Faculty of Biotechnology and Food Sciences in Nitra Journal of Microbiology, Biotechnology and Food Sciences 1338-5178 special issue 2 (Biotechnology) vol. 4 2015-02-02 2015-02-02 IMPACT OF THE T-2 TOXIN AND QUERCETIN ON RABBIT PLASMA LEVELS OF THYROTROPIN AND THYROXINE IN VIVO 57 59 EN Anton Kováčik Anton Kováčik Dagmara Packová Dagmara Packová Adriana Kolesárová Adriana Kolesárová The aim of this article was to study the effect of quercetin combination with T-2 toxin to secretion of thyrotropin and thyroxine in vivo. The rabbits were divided into the control group (without quercetin and T-2 toxin), and four experimental groups with different doses of quercetin. The thyrotropin (TSH) secretion was not significantly affected by intramuscular application of quercetin and T2-toxin against control group. The secretion of TSH was non-significatly decreased by addition of T2-toxin (group 1), but it was increased after application of quercetin with T2-toxin (groups 2, 3, 4). Significant differences between control group and experimental groups were not observed in thyroxine (T4) secretion. The highest concentration of T4 was observed in group 3 and the lowest in group 2. Our results suggested protective effect of quercetin on TSH secretion.
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