Faculty of Biotechnology and Food Sciences in Nitra Journal of Microbiology, Biotechnology and Food Sciences 1338-5178 vol. 5 2016 2016-04-01 2016-04-01 THE DIAGNOSIS AND EFFECT OF BREAST TUMORS TREATMENT IN DOGS 475 477 EN Narziev Baxtiyor Narziev Baxtiyor Yulchyiev Jasurbek Yulchyiev Jasurbek This study reports the spread of tumors of mammary gland in dogs. Changes in blood immunological and morphological parameters of affected dogs are presented. Results of immunotherapy used for activation of immune system after surgery showed various level of stimulation. Application of levamisole increase the percentage of T- and B-lymphocytes as well as the ratio of normalized subpopulations of T lymphocytes (T-helper and T-suppressor cells) indicating potential effect of levamisole. Application of BCG improved performance of T- and B-lymphocytes, but in comparison with the effect of levamisole some imbalance between subpopulations of T-helper and T-suppressor cells was detected. In the control group (simple tumor removal) different results were found indicating immunosuppressive effect of tumors.