Faculty of Biotechnology and Food Sciences in Nitra Journal of Microbiology, Biotechnology and Food Sciences 1338-5178 vol.6 2016 2016-10-03 2016-10-03 THERMOANALYTICAL STUDY OF ACECLOFENAC FORMULATIONS WITH REGULAR MAIZE STARCH AND WAXY MAIZE STARCH 828 831 EN Maristela Denck Colman Maristela Denck Colman Elaine da Silva Ramos Elaine da Silva Ramos Cristina Soltovski de Oliveira Cristina Soltovski de Oliveira Tiago Andre Denck Colman Tiago Andre Denck Colman Egon Schnitzler Egon Schnitzler Production of tablets in pharmaceutical industry often is required to mixture the active ingredient (drug) with an inert material. Starch is shown as a good alternative material to be used as excipient. Thus, in this investigation the techniques: thermogravimetry and derivative thermogravimetry (TG/DTG), differential scanning calorimetry (DSC as well as thermomicroscopy were performed with aim to verify existence of interactions between aceclofenac (2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxalacetic) with regular maize starch and waxy maize starch. Binary and physical mixtures of aceclofenac and starch in ratios 2:1, 1:1 and 1:2 (drug:starch) studied by the instrumental techniques showed that no interactions occurs between the drug and starches in any ratio, being maintained the properties of aceclofenac.
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