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February 2012, vol. 1, Special issue
pages: 632-639
Article type: Biotechnology of Biotechnology
Abstract: Transgenic founder rabbits carrying a gene construct consisting of a 2.5 kb murine whey acidic protein promoter (mWAP), 7.2 kb of the human clotting factor VIII (hFVIII) cDNA and 4.6 kb of 3’ flanking sequences of mWAP gene were crossed for five generations.
Transgenic females showed high level of recombinant hFVIII (rhFVIII) mRNA expression in biopsed mammary gland tissues. The presence of the mWAP-hFVIII transgene in rabbit genome and secretion of rhFVIII into milk of transgenic females (F1, F2, F3, F4 and F5 generation) did not have any adverse phenotypic effect on milk quality.
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