CONTROL AND CANCEROUS TISSUES OF HUMAN STOMACH, SMALL INTESTINE AND LARGE INTESTINE - THE AVERAGE CONTENT OF SODIUM AND POTASSIUM

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February 2015, vol. 4, special issue 2 (Biotechnology)
pages: 11-14
Article type: Biotechnology of Biotechnology
DOI: 10.15414/jmbfs.2015.4.special2.11-14
Abstract: Sodium and potassium regulate the total amount of water in the body and the transmission of sodium into and out of individual cells also plays a role in critical body functions. The movement of sodium is critical in generation of these electrical signals. Research was conducted on samples taken from women and men aged 20-90 years, derived from the stomach, small intestine and large intestine. Samples were dried at 80ºC for 24 hours, and then increased temperature to 105ºC and dried for seven days until dry mass was obtained. All dry material of each sample was weighted and placed in a separate mineralization tubes and mixed with 1 cm3 of 65% HNO3 and heated at 105°C for 120 minutes in a thermostat-controlled digestion block, VELP Scientifica DK 20. Metals such as sodium and potassium were detected using FAAS method. The average content of sodium in patients diagnosed with stomach cancer is lower, than in healthy person. Indicate higher mean content of sodium in the control tissues of stomach (2151,730 μg•g-1d.m.), compared to a sodium content in tissues adjacent to the tumor (1813,958 μg•g-1d.m.) and tumor tissues (2029,442 μg•g-1d.m.). In the case of colon, control tissues have lower average content of sodium (2160,886 μg•g-1d.m.), than the tissues surrounding the tumor (3325,963 μg•g-1d.m.) and tumor tissues (3037,121 μg•g-1d.m.). The potassium level is higher in the control tissues of stomach (1428,993 μg•g-1d.m.), than in the tissues adjacent to the tumor (1091,544 μg•g-1d.m.) and tumor tissues (1220,471 μg•g-1d.m.). In the large intestine higher average content of potassium is characterized by tumor tissues (2307,234 μg•g-1d.m.) and tissues adjacent to the tumor (1712,779 μg•g-1d.m.), than control tissue (1389,703 μg•g-1d.m.). Comparing this relationship with data on potassium channels, it can be assumed that in the some case of malignant transformation in the colon, potassium channels also play a big role.
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