The art of manipulating materials on atomic or molecular scales that give rise to nano sized structures and devices is dynamically pioneered and instituted into the world by the name nanotechnology. The field of nanotechnology has ratified its command and is intensifying quickly with its ongoing work in the design, characterization, synthesis, and application of materials and systems by controlling shape and size at nanometer scale. Towards solving the problem of biology and medicine, many efforts have been focused in the direction of the use of nanostructures. This study starts with the main highlights of the types of Nanoscaffolds, surface modification of these scaffolds, applications of Nanoscaffolds in tissue regrowth and terminates with interaction of cells with scaffolds. We have multiple minds all around globe as a result having different perspectives of using these novel technologies in the domain of medical treatment and diagnosis. However, there are many ethics that arose with any new technology amongst supporters and opponents but now is the time to embrace the changes and not been clung to the old ways. So, let us welcome these novel technologies which pave the way for trimming down much of our problems.